Professor Emeritus

Areas of Interest
trauma, hemorrhage, sepsis, gender dimorphism, immune functions, cardiovascular functions

Biography

Irshad H. Chaudry received a B.S. as well as an M.S. with honors from Sind University and a Ph.D. from Monash University, Australia. After his postdoctoral training at Toronto University, Canada, he was appointed as an Instructor and subsequently as an Assistant Professor at the Jewish Hospital and Washington University School of Medicine in St. Louis, Missouri. He then moved to Yale University as an Associate Professor and subsequently became a Professor. He moved to Michigan State University in 1986 as Professor and Director of Research and, in 1996, became the Director of the Center for Surgical Research at Brown University in Providence, Rhode Island. In 2000, he became the Director of the Center for Surgical Research at the University of Alabama at Birmingham. In November 2020, he became a Professor Emeritus. He has over 600 publications to his credit and is a recipient of the NIH MERIT award.

Current research interests include determining the mechanisms responsible for cellular and subcellular alterations following soft tissue trauma, bone fracture, hemorrhage, and sepsis. Additionally, the use of novel, readily available, FDA-approved, inexpensive therapeutic agents to attenuate such alterations in patients following trauma is planned. Other areas include evaluation of (1) gender dimorphism and the mechanisms responsible for producing cardiovascular and hepatocellular dysfunction and immunological alterations following trauma-hemorrhage; (2) trauma-induced changes in the hypothalamus-pituitary-adrenal axis; (3) apoptosis of immune cells; and (4) wound healing.

Specific research interests include determining the mechanism of regulation of estradiol levels by hypothalamic/pituitary factors, adrenals and steroidogenic enzyme activity and how differences in estradiol levels or the estradiol: androgen ratio due to the estrus cycle, ovariectomy, and age affect immune responses after trauma. Studies of T lymphocytes, macrophages and Kupffer cell functions using molecular biological techniques are being conducted to determine why low estradiol fails to maintain immune functions in aged females after trauma. The use of estradiol, Raloxifene, prolactin, metoclopramide, or flutamide to restore immune/cardiovascular functions following trauma should yield novel information and provide an innovative approach for improving the host responses and reducing mortality from sepsis following trauma in postmenopausal and in surgically ovariectomized patients with low estrogen activity.

Additional interests encompass the mechanisms by which androgen depletion/androgen antagonists improve cardiac performance and other organ functions after trauma. These studies also examine whether androgen depletion/androgen antagonists affect the adrenals and modify the response of the heart, liver, and vascular smooth muscle to catecholamines. The hemodynamic parameters and organ functions being measured include blood flow, circulating blood volume, cardiac output, left ventricular performance, vascular reactivity, liver, gut, adrenal, and pulmonary functions. The integration of cardiac function with other organ functions and detailed mechanistic studies at the cellular and subcellular levels using physiological, pharmacological, and molecular biology techniques to identify targets for novel treatment modalities using sex steroid antagonists/agonists or hormones should provide new information for the improved treatment of trauma victims with major blood loss and for decreasing the susceptibility to sepsis following trauma.

Selected Publications

Selected from over 650 publications in peer-reviewed journals:

Mayer A, Dodd A, Rannou-Latella J; Stephenson D, Dodd R, Ling J; Mehos C, Robertson-Benta C, Reddy SP, Kinsler R, Vermillion M, Gigliotti A, Sicard V, Lloyd A, Gill J; Lai C, Guedes V, Chaudry IH. 17α-Ethinyl Estradiol-3-Sulfate Increases Survival and Hemodynamic Functioning in a Large Animal Model of Combined Traumatic Brain Injury and Hemorrhagic Shock: A Randomized Control Trial. Crit Care 25:428. 2021.

Pretzsch E, Nieß H, Khaled NB, Bösch F, Guba M, Werner J, Angele M, Chaudry IH. Molecular Mechanisms of Ischaemia-Reperfusion Injury and Regeneration in the Liver-Shock and Surgery-Associated Changes. Int J Mol Sci 23,12942 (1-14), 2022.

Cavaillion J-M and Chaudry IH. Facing stress and inflammation: From the cell to the planet. World J Exp Med 2024 Dec 20:14(4):96422.

Aziz M, Chaudry IH, and Wang P. Extracellular CIRP: Progress from Discovery to Present. Int J Mol Sci 26, 3524, 2025.

Honors and Awards

American Heart Association Lifetime Achievement Award for Trauma Science, 2005.

President: The Shock Society, 1990-1991.

President: Surgical Infection Society, 1999-2000.

President: International Federation of Shock Societies, 2008-2012.

Recipient of NIH MERIT Award, 1999-2009.

Shock Society Scientific Achievement Award, 1997.

Editor-in-Chief, SHOCK Journal 1994-2020.

Editor-in-Chief Emeritus, SHOCK 2000-present.

Honorary Membership:

The European Shock Society since 2019.

The Shock Society since January 1, 2021.

The Society of University Surgeons since 1993.

Honorary Fellow:

The American Association for the Surgery of Trauma since 1993.

Honorary Professor:

Southern Medical University, Guangzhou, China, Sept. 2005-present.

Hebei North University, China, November 2012-present.

Honorary Director:

Microcirculation Institute, Hebei North University, China, Nov. 2012-present.

Education

Postgraduate
Monash University, Australia
Ph.D.

Contact

Phone
Academic Office: 205-790-2806

Email
ichaudry@uabmc.edu