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  • Founding and Early Growth (1964-2003)

    The Division of Pediatric Endocrinology at UAB was formally established in 1964 with the arrival of Dr. Russell Cunningham, the first trained pediatric endocrinologist in Alabama. A native of Bayou La Batre, Dr. Cunningham returned to the state following his fellowship at Boston Children’s Hospital and laid the foundation for specialized care in pediatric endocrinology. For over two decades, he served as a one-person division, delivering expert care to children with diabetes and other endocrine disorders. He pioneered a model of comprehensive, family-centered endocrine care long before it became standard. In 1990, Drs. Katrina Parker and Joycelyn Atchison joined the division, bringing a collaborative dimension to endocrine care. Dr. Cunningham retired in 1997, and following his passing in 2006, the Russell Cunningham Memorial Research Scholarship was established to support medical students with an interest in academic pediatrics.

  • New Leadership

    In mid-2000, Dr. Kenneth McCormick was appointed as the second division director of the Division of Pediatric Endocrinology. While in Wisconsin, he had been director of the core laboratory for a seven year, state-wide, NIH-funded, non-interventional, longitudinal study of Type 1 diabetes sequelae. Approximately seven months thereafter, with the addition of Dr. Gail Mick, the division had expanded to five members, some of which were part time. Drs Mick and McCormick were collaborators on numerous clinical and laboratory-based research studies. See timeline of faculty appointments below.

    Endo Faculty Timeline Note: this timeline excludes faculty with less than three years as a faculty member prior to their relocation. (Drs. Moreland, Martin and Colvin)

    Conceived as an enterprise to coordinate and enhance diabetes research and care throughout the UAB campus, the Comprehensive Diabetes Center was established in 2018, involving more than 10 departments and 250 faculty members. Several pediatric endocrinology faculty members are center members, partaking in the disparate collaborative research opportunities available at the center.

    Since 2001, the endocrine service has flourished as a clinical juggernaut, with a nearly six-fold increase in outpatient visits and inpatient admissions. Clinic census snowballed from 2,500 visits in 2001 to nearly 14,000 in 2018. Incontestably, the spike in endocrine referrals paralleled the surge in childhood obesity, especially rife in the Southeast, with its attendant co-morbidities such as type 2 diabetes, dyslipidemia, PCO syndrome, metabolic syndrome, early puberty and questionable hypothyroidism.

    Quite unanticipated, however, was the upsurge of type 1 diabetes in Alabama, appearing in younger and younger children, sometimes in those less than 5 years of age. This trend started in the late 80’s or perhaps earlier. Alabama was not alone. Type 1 diabetes expansion was observed throughout the US, even world-wide. Based on a World Health Organization survey spanning 10 years to 2006, and upon examining 10 years of records from 57 countries, it was reported that the incidence of type 1 diabetes had increased an average of 5.3% per year in North America, 4% in Asia and 3.2% in Europe. Another study, which extracted data from US diabetes registries from 2002 to 2009, corroborated the growing incidence of this chronic disease, a relative increase of 2.7% each year. The worrisome and escalating incidence in type 1 diabetes remains to this day unexplained.

    During this same time period, namely, 2001 to the present, several comprehensive, multi-specialty clinics were established at Children’s of Alabama. These clinics, bulleted below, involve physicians from other subspecialties (e.g., genetics, rehab medicine, cardiology, orthopedics, etc.), in addition to ancillary health care providers (nutritionists, child psychologists, social workers, pharmacists, etc.).

    Leadership Transtions

    • Dr. Katrina Parker (2003-2009) led the division through a period of steady clinical growth.
    • Dr. Kenneth McCormick (2011–2019), a national expert in diabetes research, expandedresearch infrastructure and multidisciplinary programs.
    • Dr. Ambika Ashraf (2019–present) currently serves as the Division Director and the Ralph Frohsin Endowed Chair in Pediatric Endocrinology. Under her leadership, the division has grown significantly in both size and national impact.

    Distinct Comprehensive Clinics

    List of comprehensive multi-disciplinary clinics, and their directors, inaugurated since 2001:

    • Type II Diabetes Clinic- Dr. Mary Lauren Scott

    • Lipid Disorders Clinic - Dr. Ambika Ashraf

    • Metabolic Bone Disorders Clinic - Dr. Ambika Ashraf and Dr. Kenneth McCormick

    • Newborn Screening (hypothyroidism and CAH) Program- Dr. Gail Mick

    • Turner Syndrome Clinic - Giovanna Beauchamp

    • Thyroid Cancer/Nodules Clinic - Dr. Pallavi Iyer

    • Cystic Fibrosis Related Diabetes Clinic - Dr. Michael Stalvey

    • Gender Clinic- Dr. Hussein Abdullatif

    • Diabetes Insulin Pump Program- Dr. Joycelyn Atchison.

  • Education and Research Within the Division

    Fellowship Program

    In 2001, the most pressing mission was to develop a fellowship program given the relentless decline in pediatric residents wishing to pursue a career in endocrinology which, alarmingly, paralleled the aforementioned nationwide rise in the incidence of both type I and II diabetes. With the proliferation of endocrine disorders and concomitant decline in the number of young endocrinologists, these antithetical trends did not bode well for endocrine care in Alabama. Fortuitously, and timely, funding for the three-year fellowship was ensured by an endowment from the Bruno Diabetes Foundation. Parenthetically, years before 2001, the largess of the Joseph Bruno family supported not only the endocrine fellowship but also multiple diabetes-related academic/clinical activities. Accreditation of the fellowship program was announced in 2002.

    Endocrine fellows are listed in chronological order:        

    • Ambika Ashraf 2003-2006

    • Whitney Brown 2005-2008

    • Amy Burton 2007-2010

    • James Gardner 2008-2011

    • Alison Lunsford 2010-2013

    • Caroline Colvin 2011-2014

    • Linnea Larson-Williams 2012-2015

    • Alexandra Martin 2013-2015

    • Shelly Mercer 2015-2018

    • Heather Choat 2016-2019

    • Bhuvana Sunil 2017-2020

    • Jessica Schmitt 2017-2020           

    • Jurhee Freese 2018-2021

    • Erin Greenup 2018-2021

    As of 2018, the division was comprised of nine board-certified endocrinologists, one instructor, nine nurse practitioners, 12 clinic nurses, six hormone stimulation testing nurses, 14 diabetes educators, five diabetes pump nurses, two nutritionists, two social workers, and one shared child family therapists. Note: many of the staff are part-time.

    • A Snapshot of Today: Advancing Excellence in Clinical Care, Research, and Education

      Today, the Division of Pediatric Endocrinology and Diabetes is recognized as a regional leader in comprehensive care, cutting-edge research and trainee development. With 11 pediatric endocrinologists, 12 nurse practitioners and over 10 certified diabetes educators, the division delivers care across a wide spectrum of endocrine disorders.

    • Clinical Care

      We manage over 15,000 outpatient visits annually, including 6,500 diabetes-specific visits, and more than 550 diabetes-related inpatient admissions. Our clinics are both high-volume and high-specialty, including:

      • Diabetes Center (Type 1 Diabetes clinic, Type 2 Diabetes clinic, High Risk Diabetes clinic, Cystic Fibrosis Related Diabetes and Endocrine Disorders clinic, Hyperglycemia clinic for Chronically Elevated A1C, and Diabetes Rescue Clinic
      • Metabolic Bone clinic
      • Muscular Dystrophy Related Bone Disease clinic
      • Newborn Screening Program
      • Polycystic Ovarian Syndrome clinic
      • Thyroid Nodule and Thyroid Cancer clinic, and Long Term Cancer Follow Up clinic
      • Turner Syndrome clinic
      • Weight Management clinic
      • Lipid clinic
      • Pediatric Gender Care clinic
    • Education and Fellowship Training

      Our ACGME-accredited fellowship program currently has the capacity to train six fellows across three years, with a curriculum emphasizing clinical acumen, multidisciplinary exposure, scholarly productivity, and professional growth. We consider ourselves to be a “fellow driven” program, not “fellow dependent”, and value clinical exposure and education for our trainees, but we do not make them do more if there are fewer fellows. We support fellows’ involvement in programs and activities that will help best prepare them for a successful career in pediatric endocrinology.

      Our faculty serve in national leadership roles across the American Board of Pediatrics, the Pediatric Endocrine Society and the American Academy of Pediatrics.

    • Featured Divisional Research

      Since 2001, research conducted by pediatric endocrinology faculty encompassed cystic fibrosis-related bone health/growth, treatment and etiology of type 1 diabetes (T1DM), lipoprotein metabolism, Vitamin D deficiency, congenital hypothyroidism, endoplasmic reticulum luminal redox effect on cortisol production in isolated microsomes and β-cell apoptosis in cystic fibrosis (CF). 

      Publications have appeared in several high-impact journals, including: J Peds, JAMA Pediatrics, Arch Internal Med, Journal of Biological Chemistry, Biochemical Journal, Journal of Steroid Biochemistry, Pediatrics, Journal of Clinical Endocrinology and Metabolism, PLOS ONE, Obesity, Journal of Clinical Lipidology, Endocrinology, Journal of Endocrinology and Biochim Biophysics Acta to name a few.

      Ongoing research studies and clinical projects include such topics as:

      • The biological defect in the CF transmembrane conductance regulator (CFTR) protein impact on both growth and bone health
      • GABA intervention in new-onset Type1 diabetes to preserve β-cell function. This pioneering double-blind, placebo- controlled, project is the first clinical trial of oral gamma aminobutyric acid (GABA) to preserve or restore endogenous insulin secretion, reduce prandial glucagon secretion, improve metabolic/glycemic control, and modulate favorably the autoimmune milieu. This is an investigator initiated study funded through JDRF.
      • Increased incidence of Type1 diabetes in African American youth, a cross-section investigation
      • Anti-N-acetylglucosamine antibodies from B lymphocytes, their prevalence and their role in the etiology of Type1 diabetes
      • Immunology of Type1 diabetes the first year post diagnosis
      • Redox regulation of endoplasmic calcium ATPase and uptake in isolated hepatic microsomes
      • Modulation of macronutrient composition for management of lipid disorders and non-alcoholic fatty liver disease.
      • Natural history of Type1 diabetes (NIH multicenter study)
      • 11-Ketotestosterone concentrations in children with CAH and other adrenal disorders
      • Cystic fibrosis diabetes and β-cell apoptosis by assaying unmethylated insulin DNA(in collaboration with Pennington Biomedical Center)
      • ECHO (Extension for Community Healthcare Outcomes) video-conferencing program covering Pediatric Diabetes and Obesity - Spring 2018
      • Diagnostic value of a second newborn screening test for congenital hypothyroidism
      • Vitamin D deficiency in pediatrics and its role in glucose homeostasis and vascular health
      • Dyslipidemia, obesity, and pre-diabete
      • Participation in at least 10 pharmaceutical-sponsored investigative drug studies concerning Type2 diabetes, growth hormone deficiency, hypophosphatasia, FGF23 excess, Prader Willi syndrome
    • Research Highlights

      Our division participates in NIH grants, including:

      • The Youth-Onset Type 2 Diabetes Consortium – Discovery study(U01DK134966, Ashraf/Gower) 
      • Dietary intervention trials in NAFLD (R01DK128457, Ashraf/Goss)

      Other notable areas of research include:

      • Epigenetics and social determinants of type 2 diabetes (Dr. Christy Foster)
      • Gut microbiome studies in pediatric metabolic disease (Dr. Ambika Ashraf)
      • Expanded access therapy for rare conditions such as MCT8 deficiency (Dr. Leen Matalka)
      • Multicenter trials in CAH and thyroid disorders (Dr. Gail Mick)
      • T1D Exchange (Dr. Mary Lauren Scott, Dr. Jessica Schmitt)
      • QI projects (Dr. Jessica Schmitt, Dr. Christy Foster)

      The division also leads in Quality Improvement initiatives through participation in the T1D Exchange, Type 2 Diabetes Education Collaboratives, and transition care innovations, ensuring equitable access to advanced diabetes technologies and empowering patients and caregivers alike.

    • Recognition and Scholarship

      Division faculty are highly productive, contributing to over a dozen peer-reviewed publications annually. Faculty are frequently invited speakers at national and international venues, including ENDO, PES, and Obesity Medicine Association conferences.

    • Looking Ahead

      With robust clinical volume, growing research collaborations, and a thriving fellowship program, the Division continues to build on its legacy while innovating for the future. The support of the Ralph Frohsin Endowment and Bruno fellows have been instrumental in propelling initiatives that improve care, expand knowledge, and train the next generation of pediatric endocrinologists.