The wisdom Study wants to apply modern medical science to breast cancer screening by determining if personalized screening is better than annual mammography and learning how to improve detection while reducing over-diagnosis and false-positive readings. Women ages 40-74, with no history of breast cancer or ductal carcinoma in situ (DCIS), are asked to join. Participation can mostly be done from home, and there are no additional medical visits outside routine visits required. Please register at www.wisdomstudy.org