Do you have Treatment-Resistant Depression? Have you tried at least one antidepressant with no relief from your depressive symptoms? Are you between the ages of 18-65? Are you interested in participating in a research study evaluating the effectiveness of a new study drug? If yes, then please call the Office of Psychiatric Research at 205-934-2484 to determine your eligibility for this study. Eligible participants will receive compensation for their time.