Precision High-Intensity Training Through Epigenetics
This study is designed to assess whether changes to genes in the body is a primary way by which specific training causes those changes in the body and responses to exercise. PHITE is a 12-wk, two-arm, single-blind, randomized, exercise dose-response trial comparing two intensities of combined exercise training – Moderate Intensity vs. High-Intensity – to determine the effect of exercise dose on performance optimization and the underlying molecular mechanisms, with a focus on epigenetics.
The term epigenetics refers to heritable changes in gene expression (active versus inactive genes) that do not involve changes to the underlying DNA sequence; i.e. a change in phenotype (the set of observable characteristics of an individual resulting from the interaction of its genotype with the environment) without a change in genotype (the genetic constitution of an individual organism). This in turn affects how cells read the genes. Epigenetic change is a regular and natural occurrence but can also be influenced by several factors including age, the environment/lifestyle, and disease state.
Come join our PHITE Club!
Benefits: Participants will receive supervised exercise training from certified trainers at our state-of-the-art exercise clinical trials facility, valuable information about their health, and upto $1000 compensation for their time.
Participants: Must be 18-27 years of age; no history of regular endurance or resistance training within the past year; must meet all other inclusion and exclusion criteria determined during screening.
Interested in participating and want to learn more?
Please complete the questionnaire below and a member of our research staff will contact you soon. You may also call 205-996-3569 or email phite@uab.edu. Thank you for your interest!